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E030330 Biotin AffiniPure Rabbit An
8-hydroxy Guanine (hydrochloride) 8
兔抗OVA（鸡卵清蛋白）多克隆抗体
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IV型胶原蛋白/4型胶原
MicroVue CICP EIA*| 货号： | B-350 |
| 抗体名： | (±)-Bay K8644 |
| 抗体英文名： | (±)-Bay K8644 |
| 靶点： | 见官方网站 |
| 浓度： | 见官方网站 |
| 应用范围： | 见官方网站 |
| 宿主： | Synthetic |
| 供应商： | 上海信裕生物科技有限公司 |
| 数量： | 大量 |
| 级别： | 高 |
| 目录编号： | B-350 |
| 抗原来源： | Synthetic |
| 保质期： | 6个月 |
| 适应物种： | 见官方网站 |
| 标记物： | 见官方网站 |
| 克隆性： | 否 |
| 保存条件： | -20°C |
| 形态： | 液体或冻干粉 |
| 亚型： | 见官方网站 |
| 免疫原： | 见官方网站 |
| 规格： | 1 mg, 5 mg, 10 mg, 50 mg |
(±)-Bay K8644
A Voltage Gated Ca2+ Channel ActivatorCat #: B-350
Sizes: 1 mg, 5 mg, 10 mg, 50 mg
Source: Synthetic
MW: 356.3 Da.
Target: L-type Ca2+ channels
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(±)-Bay K8644 is an opener of all L-type channels (CaV1 family). In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel macroscopic response.
The net activity of the racemic mix, is that of the (-)-enantiomer, agonistic activity.
(±)-Bay K8644 is a widely used L-type Ca2+ channel activator in various neuronal, muscle, endocrine, thyroid and other cell types.1-4
Alomone Labs is pleased to offer (±)-Bay K8644 (#B-350).
References
- Hess, P. et al. (1984) Nature 311, 538.
- Nowycky, M.C. et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 2178.
- Bechem, M. and Hoffman, H. (1993) Pflugers Arch. 424, 343.
- Triggle, D.J and Rompe, D. (1998) J. Neurosci. 17, 1243.
For a list of product citations in the literature, see product citations tab below. If you know of additional relevant citations for this product, please let us know.
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Alomone Labs (±)-Bay K8644 increases L-type Ca2+ currents expressed in Xenopus oocytes.
Left: I-V relation before (squares) and during (circles), bath perfusion of 5 μM (±)-Bay K8644 (#B-350). Right: An example of current response to 200 ms depolarization to +20mV (from holding potential of -100 mV) before (black) and during (pink) perfusion of (±)-Bay K8644.
Alomone Labs (±)-Bay K 8644 modulates the phosphorylation of ERK1/2 MAPK in Jurkat T cells.
Cells were preincubated with or without EGTA or Nifedipine for 20 min then stimulated with (±)-Bay K 8644 (#B-350) or with Ionomycin (#I-700) for 10 min. The cell proteins were blotted and probed with anti phospho ERK1/2 (upper panel) or with anti-ERK1/2 (lower panel).
Purity>99%.
Effective concentration1-5 μM.
Chemical name1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.
Molecular formulaC16H15F3N2O4.
CAS number71145-03-4, 93468-89-4.
Activity(±)-Bay K8644 is a dihydropyridine that acts as L-type, voltage-gated Ca2+ channel agonist. The (-)-enantiomer has strong Ca2+ channel agonist properties, whereas the (+)-enantiomer has a weak Ca2+ channel antagonist activity. The net activity of the racemic mix is L-type channels opening. In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel microscopic response1-4. (±)-Bay K8644 is also an inhibitor (by increasing the inactivation) of a shaker KV channel5.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionEthanol, Methanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to four weeks at 4°C or three months at -20°C.
Product citations
- Dahan, T. et al. (2017) Diabetes 66, 426.
- He, S. et al. (2014) J. Neurosci. 34, 5261.
- Dominguez, B. et al. (2009) Am. J. Physiol. 296, E1148.
- Husch, A. et al. (2008) J. Neurophysiol. 99, 320.
- Perissinotti, P.P. et al. (2008) Eur. J. Neurosci. 27, 1333.
- Worrell, J.W. and Levine, R.B. (2008) J. Neurophysiol. 100, 868.
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