货号: | 74155 |
保存条件: | 2-8°C |
供应商: | sigma |
英文名: | Nonactin |
CAS号: | 6833-84-7 |
保质期: | 见产品说明书 |
数量: | 大量 |
规格: | 5MG |
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无活菌素Nonactin ,from Streptomyces sp., ≥97.0% (TLC)
别名: 铵离子载体
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CAS号 6833-84-7
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经验分子式(希尔表示法) C40H64O12
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分子量 736.93
biological source from Streptomyces sp. assay ≥97.0% (TLC) storage temp. 2-8°C
产品名称
General description
may contain the homologues monactin and dinactin
Other Notes
Natural macrotetrolide
Application
Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, as an uncoupler of oxidative phosphorylation, and to inhibit surface expression of certain heat shock proteins (HSP60) 1,2.
Biochem/physiol Actions
Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation 3.