PX 12 (10 mg) | 2-[(1-methylpropyl)dithio]-1H-imidazole; PX 12

【产品形式】：艾美捷为您提供的PX 12 (10 mg)A crystalline solid

【背景资料】：PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 uM), as well as expression of VEGF (IC50 = 10.4 uM) and iNOS (IC50 = 18.1 uM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 uM) and HT-29 cells (IC50 = 2.9 uM) as well as reduced microvessel density in MCF-7 tumor xenografts. PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 uM) and Trx-1-increased expression and translation of CYP1B1.

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域。Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体。作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务。

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