Human Dkk-1 Protein, Fc Tag

货号：	DK1-H5258-1mg
供应商：	ACROBiosystems
数量：	In Stock
英文名：	Human Dkk-1 Protein, Fc Tag
规格：	1mg

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

产品描述:
Human Dkk-1, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 52.4 kDa. The predicted N-terminus is Thr 32. The reducing (R) protein migrates as 70-90 kDa in SDS-PAGE due to glycosylation.