Human CD46 Protein

货号：	CD6-H5226-1mg
供应商：	ACROBiosystems
数量：	In Stock
英文名：	Human CD46 Protein
规格：	1mg

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

产品描述:
Human CD46, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 33.6 kDa. The predicted N-terminus is Cys 35. The reducing (R) protein migrates as 55-60 kDa in SDS-PAGE due to glycosylation.