Cynomolgus CD47 Protein, Fc Tag

货号：	CD7-C5252
供应商：	ACROBiosystems
数量：	In Stock
英文名：	Cynomolgus CD47 Protein, Fc Tag
规格：	1mg/100ug

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

产品描述:
Cynomolgus CD47, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 40.5 kDa. The predicted N-terminus is Gln 4. As a result of glycosylation, the reducing (R) protein migrates as 50-66 kDa, and the non-reducing (NR) protein migrates as 100-130 kDa in SDS-PAGE.

SDS-PAGE：

Cynomolgus / Rhesus macaque CD47, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 

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http://www.acrobiosystems.cn/P133-Fc_Tag.html
 

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