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ActiveMax® Recombinant Human IL-1 alpha / IL-1F1

产品价格: ¥7735.00

最小起订量:暂无 可售数量:暂无

发货时限:
暂无
所在地区:
中国北京
有效期至:
长期有效
最后更新:
2021-03-26 01:30:01
浏览次数:
25
企业信息

产品详情

品牌名称:
ACROBiosystems
货号: ILA-H4213
供应商: ACROBiosystems
数量: In Stock
英文名: ActiveMax® Recombinant Human IL-1 alpha / IL-1F1
规格: 50ug
内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>97% as determined by SDS-PAGE.

活性:
(1) Measured by its binding ability in a functional ELISA.Immobilized Human IL-1 RII, Fc Tag (Cat# IL2-H4256) at 10 μg/mL (100 µL/well),can bind ActiveMax® Human IL-1 alpha (Cat# ILA-H4213).The EC50 is typically 0.5-5 μg/mL.(2) The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse D10S cells.The ED50 < 1pg/mL, corresponding to a specific activity of >1,000,000,000 Unit/mg.

产品背景:
Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.

产品描述:
ActiveMax® Human IL-1 alpha contains no "tag", and has a calculated MW of 18 kDa. The reducing (R) protein migrates as 19-22 kDa in SDS-PAGE due to Glycosylation.
温馨提示:不可用于临床治疗。

免责声明

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