Human BAFFR / TNFRSF13C Protein, Fc Tag

货号：	BAR-H5257
供应商：	ACROBiosystems
数量：	In Stock
英文名：	Human BAFFR / TNFRSF13C Protein, Fc Tag
规格：	100ug/1mg

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Human BAFF, His Tag (Catalog # BAF-H5248) at 5 μg/mL (100 μL/well) can bind Human BAFFR, Fc Tag (Catalog # BAR-H5257) with a linear range of 2-31 ng/mL.

产品背景:
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

产品描述:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
 

SDS-PAGE

Human BAFFR / TNFRSF13C, Fc Tag on SDS-PAGE  under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.