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Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag

产品价格: ¥2600.00

最小起订量:暂无 可售数量:暂无

发货时限:
暂无
所在地区:
中国北京
有效期至:
长期有效
最后更新:
2021-05-07 01:30:01
浏览次数:
24
企业信息

产品详情

品牌名称:
ACROBiosystems
货号: CSR-C5252
供应商: ACROBiosystems
数量: In Stock
英文名: Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
规格: 100ug/1mg
内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:

产品背景:
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

产品描述:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81.9 kDa. As a result of glycosylation, the protein migrates as 110-125 kDa under reducing (R) condition, and 200- 240 kDa under non-reducing (NR) condition (SDS-PAGE).
 

SDS-PAGE


Cynomolgus M-CSF R, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
温馨提示:不可用于临床治疗。

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