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维真生物 预制人类 miRNA 腺病毒
Dual- Luciferase® 双萤光素酶报告基
DH5α
[VIP第1年] 指数:1
CD131 / CSF2RB / IL3
小鼠 H2-EA-PS 基因全| 货号： | HG10907-M |
| 数量： | 大量 |
| 供应商： | SinoBiological |
| 英文名： | Homo sapiens CDK9/CDC2L4 DNA ORF Clone |
官方网址：http://www.sinobiological.cn/CNDP1-Antibody-g-525.html
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Glutamate Carboxypeptidase-Like Protein 2 ( CNDP1 / CN1 ) Antibody
CNDP1 / CN1抗体产品信息
| 免疫原 : | Human cell-derived rhCNDP1 ( Catalog#10077-H08H ) |
| 克隆号 : | 5E11B6G5 |
| 抗体宿主 : | Mouse IgG1 |
| 缓冲液 : | 0.2 μm filtered solution in PBS with 5% trehalose |
| 制备方法 : | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Carnosine Dipeptidase 1 (rhCNDP1; Catalog#10077-H08H; aa 27-508; NP_116038.4). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
CNDP1 / CN1抗体使用指南
| 特异性 : | Human CNDP1 / CN1 |
| No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. | |
| Western blot : | This antibody can be used at 1-2μg/mL with the appropriate secondary reagents to detect CNDP1 in WB. |
| 储存方法 : | This antibody can be stored at 2℃-8℃ for 1 month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
CNDP1 / CN1抗体背景综述
CNDP1, also known as glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. This protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. The CN1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protects against the adverse effects of high glucose levels on renal cells. In addition, this protein is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
参考文献
1. Teufel, Mm. et al., 2004, J. Biol. Chem. 278 : 6521-6532.
2. Riedl, E. et al., 2007, Diabetes. 56: 2410-2413.
3. Sauerhofer, S. et al., 2007, Diabetes. 56: 2425-2432.
