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醋酸特立帕肽 Teriparatide Acetate CAS:52232-67-4

产品价格: 面议

最小起订量:暂无 可售数量:暂无

发货时限:
暂无
所在地区:
中国上海
有效期至:
长期有效
最后更新:
2021-04-06 01:30:02
浏览次数:
21

产品详情

品牌名称:
Chemleader
货号: C14242
CAS号: 52232-67-4
供应商: 凯立德生物
数量: 5/3/2/35
英文名: Teriparatide Acetate
保质期: 2年
保存条件: 2-8℃
规格: 20mg/100mg/1g/5g
​中文名称:醋酸特立帕肽
英文名称:Teriparatide acetate
CAS:52232-67-4
分子式:C181H291N55O51S2.C2H4O2 
分子量:4177.77
生物活性:
Teriparatide is a PHT agonist, binds to the receptor for PHT present in bone and stimulates the G-protein-related production of cyclic monophosphate. THA recombinant 1-34 amino acid segment THA.
In vitro: THA may also stimulate mesenchymal stem cell proliferation and stem cell maturation in the musculoskeletal lineage. PTH(1-34) is able to maintain serum calcium and phosphate levels and to improve quality of life (QOL) with postsurgical hypoparathyroidism with no serious side effects. stimulates modeling- and remodeling-based bone formation through natural homeostatic system.increase the cortical thickness and porosity.
In vivo: The adminstration for TPTD is 20 μg/kg (subcutaneously )
TPTD administration increased the BMC, volumetric BMD, and cortical thickness and decreased the pore ratio.
相关文献:
[1]. Palermo A et al. PTH(1-34) for the primary prevention of post-thyroidectomy hypocalcemia: the THYPOS trial. J Clin Endocrinol Metab. 2016 Aug 15
[2]. Sugiyama T et al. Letter to the Editor: Combination Treatment With Teriparatide and Denosumab in Osteoporosis. J Clin Endocrinol Metab. 2016 Aug;101(8):L80-1.
[3]. Iwamoto J et al. Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits: A HR-QCT Study. Calcif Tissue Int. 2016 Jul 27.
[4]. Manabe T et al. Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone. 2007 Jun;40(6):1475-82.
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温馨提示:不可用于临床治疗。

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