货号: | C14242 |
CAS号: | 52232-67-4 |
供应商: | 凯立德生物 |
数量: | 5/3/2/35 |
英文名: | Teriparatide Acetate |
保质期: | 2年 |
保存条件: | 2-8℃ |
规格: | 20mg/100mg/1g/5g |
英文名称:Teriparatide acetate
CAS:52232-67-4
分子式:C181H291N55O51S2.C2H4O2
分子量:4177.77
生物活性:
Teriparatide is a PHT agonist, binds to the receptor for PHT present in bone and stimulates the G-protein-related production of cyclic monophosphate. THA recombinant 1-34 amino acid segment THA.
In vitro: THA may also stimulate mesenchymal stem cell proliferation and stem cell maturation in the musculoskeletal lineage. PTH(1-34) is able to maintain serum calcium and phosphate levels and to improve quality of life (QOL) with postsurgical hypoparathyroidism with no serious side effects. stimulates modeling- and remodeling-based bone formation through natural homeostatic system.increase the cortical thickness and porosity.
In vivo: The adminstration for TPTD is 20 μg/kg (subcutaneously )
TPTD administration increased the BMC, volumetric BMD, and cortical thickness and decreased the pore ratio.
相关文献:
[1]. Palermo A et al. PTH(1-34) for the primary prevention of post-thyroidectomy hypocalcemia: the THYPOS trial. J Clin Endocrinol Metab. 2016 Aug 15
[2]. Sugiyama T et al. Letter to the Editor: Combination Treatment With Teriparatide and Denosumab in Osteoporosis. J Clin Endocrinol Metab. 2016 Aug;101(8):L80-1.
[3]. Iwamoto J et al. Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits: A HR-QCT Study. Calcif Tissue Int. 2016 Jul 27.
[4]. Manabe T et al. Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone. 2007 Jun;40(6):1475-82.
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