点击图片查看原图

8-Isoprostane EIA Kit

产品价格: 面议

最小起订量:暂无 可售数量:暂无

发货时限:
暂无
所在地区:
中国广东广州市
有效期至:
长期有效
最后更新:
2020-09-14 02:00:01
浏览次数:
23
企业信息

产品详情

品牌名称:
caymanchen
货号: 516351
数量: 大量
规格: 96 wells 、480 wells

Limit of detection: 80% B/B0: 2.7 pg/ml · Sensitivity: 50% B/B0: 10 pg/ml · The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. Isoprostanes appear as artifacts in tissue and plasma samples which have undergone oxidative degradation during prolonged or improper storage. They also appear in the plasma and urine under normal conditions and are elevated by oxidative stress. At least one of the isoprostanes, 8-isoprostane (8-epi PGF), has been shown to have biological activity. It is a potent pulmonary and renal vasoconstrictor1 and has been implicated as a causative mediator of hepatorenal syndrome and pulmonary oxygen toxicity.2 8-Isoprostane has been proposed as a marker of antioxidant deficiency and oxidative stress and elevated levels have been found in heavy smokers.3 8-Isoprostane levels are also a relative indicator of sample integrity for lipid-containing samples such as serum, plasma, and whole cell preparations.4 Plasma from healthy volunteers contains modest amounts of 8-isoprostane (40-100 pg/ml) that increase with the age of the test subject.5 Normal human urinary levels range from 10-50 ng/mmol creatinine, which is an order of magnitude higher than many enzymatically derived eicosanoids.5,6
1  Banerjee, M., Kang, K.H., Morrow, J.D., et al. Effects of a novel prostaglandin, 8-epi-PGF, in rabbit lung in situ. Am J Physiol 263 H660-H663 (1992).
2  Vacchiano, C.A., Tempel, G.E. Role of nonenzymatically generated prostanoid, 8-iso-PGF, in pulmonary oxygen toxicity. J Appl Physiol 77 2912-2917 (1994).
3  Morrow, J.D., Frei, B., Longmire, A.W., et al. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N Engl J Med 332 1198-1203 (1995).
4  Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).
5  Wang, Z., Ciabattoni, G., Créminon, C., et al. Immunological characterization of urinary 8-epi-prostaglandin F excretion in man. J Pharmacol Exp Ther 275 94-100 (1995).
6  Reilly, M.P., Barry, P., Lawson, J.A., et al. Urinary 8-epi PGF: An index of oxidant stress in vivo. Fibrinolysis & Proteolysis 11 81-84 (1997).

免责声明

本网页所展示的有关【8-Isoprostane EIA Kit】的信息/图片/参数等由的会员【广州威佳科技有限公司 】提供,由【生物实验采购网】会员【广州威佳科技有限公司 】自行对信息/图片/参数等的真实性、准确性和合法性负责,本平台(本网站)仅提供展示服务,请谨慎交易,因交易而产生的法 律关系及法律纠纷由您自行协商解决,本平台(本网站)对此不承担任何责任。您在本网页可以浏览【8-Isoprostane EIA Kit】有关的信息/图片/价格等及提供 【8-Isoprostane EIA Kit】的商家公司简介、联系方式等信息。

在您的合法权益受到侵害时,请您致电,我们将竭诚为您服务,感谢您对【生物实验采购网】的关注与支持!

网站首页 | 关于我们 | 联系方式 | 使用协议 | 版权隐私 | 网站地图  |  排名推广  |  广告服务  |  积分换礼  |  网站留言  |  RSS订阅  |  违规举报
 
免责声明:本站有部分内容来自互联网,如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权,请来电或致函告之,本网站将在规定时间内给予删除等相关处理。