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Cdc42 Protein

产品价格: ¥2600.00

最小起订量:暂无 可售数量:暂无

发货时限:
暂无
所在地区:
中国湖北武汉市
有效期至:
长期有效
最后更新:
2021-04-23 01:30:01
浏览次数:
11

产品详情

品牌名称:
10107
货号: 10107
CAS号: 10107
供应商: 10107
数量: 30000
英文名: Cdc42 Protein
保质期: 一年
保存条件: -20℃
规格: 100μl
Cdc42 Protein [10107]
[100 µg]
 

 

Catalog Number:  10107
Product Name:  Cdc42 Protein
Synonyms:  Cell division cycle 42, G25K, CDC42Hs
Source:   Human, recombinant full length, His6-tag
Expression Host:   E. coli
Molecular Weight:   21 kDa
Purity:   >95% by SDS-PAGE
Introduction:   Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs).
Amino Acid Sequence   (1-191)
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRL 
RPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQ 
KPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
Properties
Physical Appearance (form):   Dissolved in 20mM Tris-HCl, pH8.0, 150mM NaCl.
Physical Appearance (form):  White or clear
Concentration:  1 mg/mL
Storage:   -80°C
Preparation Instructions:  
Centrifuge the vial before open the cap and reconstitute in water. Adding of 10 mM β-mercaptoethanol or 1 mM DTT into the solution to protect the protein is recommended and using of non-ionic detergents such as n-Dodecyl β-D-maltoside (DoDM) or polyethylene detergents (e.g. C12E10) also help to stabilize the protein. Avoid repeated freezing and thawing after reconstitution. The purity of His-tagged Cdc42 was determined by SDS- PAGE and Coomassie Brilliant Blue Staining.
References:  
1. Garrett, W. S. . et al., Cell 102: 325-334, 2000. 
2. Irie, F. et al., Nature Neurosci. 5: 1117-1118, 2002. 
3. Kawasaki, Y. et al., Oncogene 26: 7620-7627, 2007. 
4. Manser, E. et al., Nature 363: 364-367, 1993. 
5. Musch, A. et al., EMBO J. 20: 2171-2179, 2001. 
6. Nalbant, P. et al., Science 305: 1615-1619, 2004. 
7. Shen, Y. et al., Dev. Cell 14: 342-353, 2008. 
8. Wu, W. J. et al., Nature 405: 800-804, 2000. 
9. Wu, X. et al., Genes Dev. 20: 571-585, 2006. 
10. Zheng, Y. et al., J. Biol. Chem. 271: 33169-33172, 1996.
Datasheet:  
Publications:
1.  Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling
    PLoS Pathog. 2013 Jan;9(1):e1003142
2.  Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
    Cytokine. 2012 Jan;57(1):158-68
3.  Invadopodia and rolling-type motility are specific features of highly invasive p190bcr-abl leukemic cells
    European Journal of Cell Biology Volume 91, Issues 11–12, November–December 2012, Pages 978–987
4.  Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
    J Cell Biol. 2012 Aug 20;198(4):677-93
5.  Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
    Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L32-42
6.  The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor beta-Stimulated Aortic Endothelial Cells
    Mol Cell Biol. 2011 Nov;31(22):4430-41
7.  MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex
    PLoS One. 2013 Jul 19;8(7):e70123
8.  p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
    PLoS One. 2013 Sep 3;8(9):e73063
9.  The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
    J Biol Chem. 2014 Jun 27;289(26):18347-59
10.  Cdc42 Inhibitor and Uses Thereof
    United States Patent Application 20140194451
11.  The α4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
    Molecular Pharmacology January 2014 vol. 85 no. 1 50-61

 

温馨提示:不可用于临床治疗。

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