Rho family pan antibody_抗体_试剂_供应

货号：	21035
抗体名：	抗-Cdc42+Rac1+RhoA 兔多克隆抗体
抗体英文名：	Anti-Cdc42+Rac1+RhoA Rabbit Polyclonal Antibody
靶点：	CDC42+RAC1+RHOA
浓度：	0.2mg/ml
应用范围：	ELISA, WB, IHC
宿主：	兔
供应商：	NewEastbio
数量：	30
级别：	实验级
目录编号：	21035
保质期：	1年
适应物种：	脊椎动物
克隆性：	是
保存条件：	-20℃
形态：	液体
亚型：	IgG
免疫原：	A synthetic peptide from the N -terminal region common among Cdc42, Rac1, and RhoA.
规格：	100ul

Rho family pan antibody (Cdc42+Rac1+RhoA) [21035]
[100 µL]

Catalog Number: 21035

Gene Symbol: CDC42+RAC1+RHOA

Description: Anti-Cdc42+Rac1+RhoA Rabbit Polyclonal Antibody

Background: Small GTPases are a super-family of cellular signaling regulators. The Rho sub-family GTPases regulate cell motility, cell division, and gene transcription.

Immunogen: A synthetic peptide from the N -terminal region common among Cdc42, Rac1, and RhoA.

Applications: ELISA, WB, IHC

Recommended Dilutions: ELISA 1:100-1:5000
WB 1:100-1:2000
IHC 1:100-1:1000

Concentration: 0.2 mg/ml

Host: Rabbit

Format: Liquid

Clonality: Polyclonal

Isotype: IgG

Purity: Purified from serum

Storage buffer:

Preservative: no

Constituents: PBS (without Mg²⁺ and Ca²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Rho family pan antibody recognizes Cdc42, Rac1, and RhoA from vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Western blot:

EC-1 whole-cell lysate was used for Western blot with the polyclonal Rho family pan antibody (cat # 21035).

Publications:

1. Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling
PLoS Pathog. 2013 Jan;9(1):e1003142

2. Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
Cytokine. 2012 Jan;57(1):158-68

3. Invadopodia and rolling-type motility are specific features of highly invasive p190bcr-abl leukemic cells
European Journal of Cell Biology Volume 91, Issues 11–12, November–December 2012, Pages 978–987

4. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
J Cell Biol. 2012 Aug 20;198(4):677-93

5. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L32-42

6. The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor beta-Stimulated Aortic Endothelial Cells
Mol Cell Biol. 2011 Nov;31(22):4430-41

7. MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex
PLoS One. 2013 Jul 19;8(7):e70123

8. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
PLoS One. 2013 Sep 3;8(9):e73063

9. The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
J Biol Chem. 2014 Jun 27;289(26):18347-59

10. Cdc42 Inhibitor and Uses Thereof
United States Patent Application 20140194451

11. The α4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
Molecular Pharmacology January 2014 vol. 85 no. 1 50-61

温馨提示：不可用于临床治疗。

Rho family pan antibody

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