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蛋白质二硫键异构酶抗体
11213865001 Roche Collagenase P, 50
BD流式抗体554865Rat CD25 FITC OX-39
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| 货号： | OAPB01848 |
| 抗体英文名： | ITCH Antibody - N-terminal (OAPB01848) |
| 靶点： | ITCH |
| 应用范围： | ELISA, WB |
| 宿主： | Rabbit |
| 适应物种： | Human, Mouse, Rat |
| 克隆性： | 否 |
| 保存条件： | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| 形态： | Liquid, 1 mg/mL provided in PBS containing 0.02% sodium azide. |
| 亚型： | IgG |
| 免疫原： | ITCH antibody was raised against a 15 amino acid peptide near the amino terminus of human ITCH |
| 规格： | 100 ug |
Swissprot Id: Q96J02
The Itchy E3 ubiquitin protein ligase (ITCH) is a member of the Nedd4 family of HECT domain E3 ubiquitin ligases (1). HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. ITCH plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses (2). In B cells, ITCH is thought to associate with latent membrane protein 2A (LMP2A) of Epstein-Barr virus, specifically down-regulating its activity in B cell signaling (3). Mutations in this gene are a cause of syndromic multisystem autoimmune disease (4). - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAPB01848
3T3 cell lysate
Western blot analysis of ITCH in 3T3 cell lysate with ITCH antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
温馨提示：不可用于临床治疗。
