甩尾测痛仪37360

 甩尾测痛仪主要是用于测量大、小鼠尾巴部受红外热刺激的痛觉阈值。实验时，当动物感觉疼痛，尾巴会轻敲台面，内置传感器会立刻检测到，停止计时和关闭光源，即仪器自动记录反应时间和光源强度。数据可通过U盘、USB数据线等导出。

甩尾测痛仪中有一可调强度的红外光源，其红外光主要是通过一抛物面反射镜聚焦在实验动物的尾巴上。实验时，操作人员将实验动物置于仪器上，把动物的尾巴放在红外光源处，接受刺激。特征仪器自动记录实验数据精度高，避免人为因素引起的误差包含U盘和软件优点可独立工作，也可连接电脑使用 仪器工作台表面无突出和遮挡物件 操作方便，实验重复性好规格；命令：软键和脚踏板连接电脑：DELTA 9-pin连接头，USB连线数据读取：液晶显示电源：universal mains 85-264 VAC, 50-60Hz  

打印：微型热敏打印机（需另外购买）工作温度：15° - 30° C开始：红外开关声级：< 70 dB红外强度：10-99级间可调反应时间：液晶屏显示，分辨率为0.1s校准：红外热辐射计（需另外购买）截止时间：预置，15 - 60 s间  文献关于方法  - F.E. D’Amour & D.L. Smith: "A Method for Determining Loss of Pain Sensation." J. Pharmacol. Exp. Therap. 72: 74-79, 1941. - D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat”Pain 59: 85-97, 1994.   涉及疼痛甩尾 - C. Dawson et alia: “ Dexmedetomidine Enhances Analgesic Action of Nitrous Oxide” Anesthesiology 100 (4): 894−904, 2004 - P. Tolu et alia: “ Effects of Long-Term Acetyl-L-carnitine Administation in Rats: I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection Toward Acute Stress Exposure” Neuropsychopharmacol. 27 (3): 410-420, 2002 - R. Nadeson et alia: “ Potentiation by Ketamine of Fentanyl Antinociception. I. An Experimental Study in Rats Showing that Ketamine Administered by Non-Spinal Routes Targets Spinal Cord Antinociceptive Systems” Br. J. Anaesthesia 88 (5): 685−691, 2002   - L. Jasmin et alia: “ The NK1 Receptor mediates Both the Hyperalgesia and the Resistance to Morphine in Mice Lacking Nor***” PNAS 99 (2): 1029−1034, 2002   - G.L. Fraser et alia: “ Antihyperalgesic Effects of Opioid Agonists in a Rat Model of Chronic Inflammation” Br. J. Pharmacol. 129: 1668−1672, 2000   - M. Xu et alia: “ Effects of Radolmidine, a Novel α2- Adrenergic Agonist Compared with Dexmedetomidine in Different Pain Models in the Rat” Anesthesiology 93 (2): 473−481, 2000   -  A. Köster et alia: “Targeted Disruption of the Orphanin Fq/Nociceptin Gene Increases Stress Susceptibility and Impairs Stress Adaptation In Mice” Neurobiology 96 (18): 10444-10449, 1999   - I. Sora et alia: “Opiate Receptor Knockout Mice Define µ Receptor Roles in Endogenous Nociceptive Responses and Morphine-Induced Analgesia” Neurobiology 94: 1544-1549, 1997   - C.T. Dourish et alia: "The Selective CCK-B Receptor Antagonist L-365,260 Enhances Morphine Analgesia and Prevents Morphine Tolerance in the Rat" Europ. J. Pharmacol. 176: 35-44, 1990   - P.W. Nance & J. Sawinok: "Substance P-Induced Long-Term Blockade of Spinal Adrenergic Analgesia: Reversal by Morphine and Naloxone" J. Pharmacol. Exp. Therap. Vol. 240, No. 3: 972-977